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Esser C, Scheffner M, Hohfeld J (2005) The chaperone-associated ubiquitin ligase CHIP isable to target p53 for proteasomal degradation. Multicentre experience withextralevator abdominoperineal excision for low rectal cancer. The introduction of delayed surgical repairand ECMO in the 1990s was associated withan improved survival in centres with previoushigh mortality rates.